This trial will evaluate the safety and efficacy of pembrolizumab (MK-3475) in combination with platinum doublet neoadjuvant chemotherapy (NAC) before surgery [neoadjuvant phase], followed by pembrolizumab alone after surgery [adjuvant phase] in participants with resectable stage II, IIIA, and resectable IIIB (T3-4N2) non-small cell lung cancer (NSCLC).
Modification of LPS is not the only mechanism of resistance to polymyxins. In K.pneumoniae, the presence of capsule is critical for polymyxin resistance. 35 In S.Typhimurium, the gene mig-14 is involved in polymyxin resistance. 34 While the specific mechanism of action is undefined, it is not related to LPS modification. 34 In Vibrio cholerae, resistance to polymyxin is dependent on the outer ...
The purpose of this study is to assess the efficacy and safety of stereotactic body radiotherapy (SBRT) plus pembrolizumab (MK-3475) in the treatment of adult participants with medically inoperable Stage I or IIA non-small cell lung cancer (NSCLC). The primary study hypotheses are: SBRT plus ...
This multicenter, randomized, double-blind study will evaluate the efficacy, safety, and pharmacokinetics of atezolizumab (MPDL3280A) administered with nab-paclitaxel compared with placebo in combination with nab-paclitaxel in participants with locally advanced or metastatic triple-negative breast cancer (TNBC) who have not received prior systemic therapy for metastatic breast cancer (mBC ...
Operation Smile counts on the caring of students, parents, and educators to help us bring as many smiles as we can to children all across the world. From clubs and fundraisers, to mission trips and signature events, there are plenty of opportunities to get involved!
Jan 30, 2017· Study of Nivolumab in Combination With Ipilimumab or Standard of Care Chemotherapy Compared to the Standard of Care Chemotherapy Alone in Treatment of Participants With Untreated Inoperable or Metastatic Urothelial Cancer - Full Text View.
In a recent article, Lee et al. reported the occurrence of an increase in MICs for polymyxin B during therapy in 3 of 16 patients treated with this drug for carbapenem-resistant Klebsiella pneumoniae infections.This report is very important, since polymyxins, polymyxin B and colistin, are last-resort drugs for the treatment of multidrug-resistant gram-negative bacteria (7, 9) and rapid ...
The purpose of this study is to assess whether copanlisib in combination with standard immunochemotherapy (rituximab in combination with bendamustine [R-B] and rituximab in combination with a 4 drug combination of cyclophosphamide, doxorubicin, vincristine and prednisone/prednisolone [R-CHOP]) is effective and safe, compared with placebo in combination with standard …
1: Editorial: Combination Therapy as First-Line Treatment in Metastatic Renal-Cell Carcinoma. 2019 Escudier, Bernard.· From the Gustave Roussy Cancer Campus, Villejuif, France. · N Engl J Med · Pubmed #30779526. ABSTRACT: -- No abstract -- 2: Editorial: Sorafenib-Sunitinib Sequence: The Jury Is Out. 2015 Albiges, Laurence / Escudier, Bernard.· Genitourinary Oncology, Gustave Roussy ...
Purpose: Long‐term medical management of epileptic drop attacks is usually unsatisfactory and more effective antiepileptic drug (AED) regimens are needed. The present study aimed at providing proof of concept that previously refractory epileptic drop attacks could be significantly and safely controlled by the specific combination of valproate, lamotrigine, and a benzodiazepine.
The identification of the cause of an epileptic seizure is a key element in the clinical management of all patients. In recent decades, advances in theory, neuroimaging, molecular genetics and molecular chemistry have revolutionized our ability to investigate and identify the underlying cause.
From the Departments of Urology (A.M., M.-O.T.) and Medical Oncology (S.O.), Hôpital Européen Georges-Pompidou, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Descartes, and Paris Descartes Necker-Cochin Clinical Research Unit, AP-HP (S.C.), Paris, the Department of Medical Oncology, Bordeaux University Hospital (A.R.), the ...
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Hospital Sao Vicente De Paulo Passo Fundo, RIO Grande DO SUL 99010-080 Brazil Recruiting: Nicolas Lazaretti, Site 0119 +555421034130: Hospital Sao Lucas Da Pucrs Porto Alegre, RIO Grande DO SUL 90610-000 Brazil Recruiting: Andre Fay, Site 0020 +555181181602: Centro de Pesquisas Oncologicas de Santa Catarina-CEPON
Operation Smile counts on the caring of students, parents, and educators to help us bring as many smiles as we can to children all across the world. From clubs and fundraisers, to mission trips and signature events, there are plenty of opportunities to get involved!
Acute Myeloid Leukaemia (AML) is an aggressive and rare cancer of myeloid cells (a white blood cell responsible for fighting infections). Successful treatment of AML is dependent on what subtype of AML the participant has, and the age of the participant when diagnosed. Venetoclax is an experimental drug that kills cancer cells by blocking a protein (part of a cell) that allows cancer cells to ...